Evaluation of the Profile and Mechanism of Neurotoxicity of Water-Soluble [Cu(P)4]PF6 and [Au(P)4]PF6 (P = thp or PTA) Anticancer Complexes.

Ceresa, C; Nicolini, G; Semperboni, S; Gandin, V; Monfrini, M; Avezza, F; Alberti, P; Bravin, A; Pellei, M; Santini, C; Cavaletti, Guido

Evaluation of the Profile and Mechanism of Neurotoxicity of Water-Soluble [Cu(P)₄]PF₆ and [Au(P)₄]PF₆ (P = thp or PTA) Anticancer Complexes.

Ceresa, C; Nicolini, G; Semperboni, S; Gandin, V; Monfrini, M; Avezza, F; Alberti, P; Bravin, A; Pellei, M; Santini, C; Cavaletti, Guido.

Afiliación

Ceresa C; Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore, 48, 20900, Monza, MB, Italy.
Nicolini G; Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore, 48, 20900, Monza, MB, Italy.
Semperboni S; Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore, 48, 20900, Monza, MB, Italy.
Gandin V; PhD Program in Neuroscience, University of Milano-Bicocca, Monza, Italy.
Monfrini M; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Avezza F; Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore, 48, 20900, Monza, MB, Italy.
Alberti P; Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore, 48, 20900, Monza, MB, Italy.
Bravin A; Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore, 48, 20900, Monza, MB, Italy.
Pellei M; PhD Program in Neuroscience, University of Milano-Bicocca, Monza, Italy.
Santini C; ID17, European Synchrotron Radiation Facility, Grenoble, France.
Cavaletti G; School of Science and Technology - Chemistry Division, University of Camerino, Camerino, Italy.

Neurotox Res ; 34(1): 93-108, 2018 07.

Article en En | MEDLINE | ID: mdl-29344837

Asunto(s)

Adamantano/análogos & derivados; Antineoplásicos/farmacología; Neuronas/efectos de los fármacos; Compuestos Organofosforados/química; Compuestos Organofosforados/farmacología; Potenciales de Acción/efectos de los fármacos; Adamantano/química; Adamantano/farmacología; Animales; Antineoplásicos/química; Bortezomib/farmacología; Carcinoma/patología; Línea Celular Tumoral; Células Cultivadas; Cisplatino/farmacología; Cobre/metabolismo; Relación Dosis-Respuesta a Droga; Embrión de Mamíferos; Femenino; Ganglios Espinales/citología; Oro/metabolismo; Humanos; Ratones; Ratones Endogámicos C57BL; Proyección Neuronal/efectos de la radiación; Nervios Periféricos/efectos de los fármacos; Nervios Periféricos/fisiología; Polimerizacion/efectos de los fármacos; Complejo de la Endopetidasa Proteasomal/metabolismo; Ratas; Ratas Sprague-Dawley; Tubulina (Proteína)/metabolismo

Palabras clave

Chemotherapy; Metal-based drug; Neurotoxicity; Phosphane complexes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organofosforados / Adamantano / Neuronas / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Neurotox Res Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Italia

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