[Nephrotic syndrome and acute interstitial nephritis after phenylbutazone]. / Nephrotisches Syndrom und akute interstitielle Nephritis nach Phenylbutazon.
Schweiz Med Wochenschr
; 115(44): 1551-5, 1985 Nov 02.
Article
en De
| MEDLINE
| ID: mdl-2934808
ABSTRACT
A 59-year-old man developed a nephrotic syndrome and mild renal failure after treatment with phenylbutazone. Light microscope examination of a renal biopsy specimen showed minimal glomerular alterations, and electron microscopy showed diffuse fusion of epithelial cell foot processes without immune deposits. The interstitium revealed focal lymphocyte infiltrates identified as activated T-cells by immune histologic differentiation. The unusual combination of nephrotic syndrome with acute interstitial nephritis is a rare adverse reaction of nonsteroidal antiinflammatory drugs (NSAID). A disordered cell-mediated immunity could lead to interstitial infiltration of T-lymphocytes which, releasing lymphokines and a vascular permeability factor, cause the glomerular proteinuria. In addition, NSAID inhibition of prostaglandin synthesis may enhance production of these lymphocyte-derived substances. Since the nephrotic syndrome persisted 5 months after withdrawal of phenylbutazone, steroid therapy was initiated and 2 months later the renal insufficiency and proteinuria were resolved.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenilbutazona
/
Nefritis Intersticial
/
Síndrome Nefrótico
Tipo de estudio:
Prognostic_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
De
Revista:
Schweiz Med Wochenschr
Año:
1985
Tipo del documento:
Article