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GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21.
Wiemels, Joseph L; Walsh, Kyle M; de Smith, Adam J; Metayer, Catherine; Gonseth, Semira; Hansen, Helen M; Francis, Stephen S; Ojha, Juhi; Smirnov, Ivan; Barcellos, Lisa; Xiao, Xiaorong; Morimoto, Libby; McKean-Cowdin, Roberta; Wang, Rong; Yu, Herbert; Hoh, Josephine; DeWan, Andrew T; Ma, Xiaomei.
Afiliación
  • Wiemels JL; Department of Epidemiology and Biostatistics, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA. joe.wiemels@ucsf.edu.
  • Walsh KM; Department of Neurological Surgery, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA. joe.wiemels@ucsf.edu.
  • de Smith AJ; Institute for Human Genetics, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA. joe.wiemels@ucsf.edu.
  • Metayer C; Department of Preventative Medicine, University of Southern California, SSB 318D 2001 N. Soto Street, Los Angeles, CA, 90033, USA. joe.wiemels@ucsf.edu.
  • Gonseth S; Department of Epidemiology and Biostatistics, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.
  • Hansen HM; Department of Neurological Surgery, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.
  • Francis SS; Department of Epidemiology and Biostatistics, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.
  • Ojha J; School of Public Health, University of California Berkeley, 1950 University Avenue, Suite 460, Berkeley, CA, 94720, USA.
  • Smirnov I; Department of Epidemiology and Biostatistics, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.
  • Barcellos L; Department of Preventative Medicine, University of Southern California, SSB 318D 2001 N. Soto Street, Los Angeles, CA, 90033, USA.
  • Xiao X; Department of Neurological Surgery, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.
  • Morimoto L; Department of Epidemiology and Biostatistics, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.
  • McKean-Cowdin R; Department of Epidemiology, School of Community Health Sciences, University of Nevada Reno, 1664 N. Virginia Street, Reno, NV, 89557, USA.
  • Wang R; Department of Epidemiology and Biostatistics, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.
  • Yu H; Department of Neurological Surgery, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.
  • Hoh J; School of Public Health, University of California Berkeley, 1950 University Avenue, Suite 460, Berkeley, CA, 94720, USA.
  • DeWan AT; School of Public Health, University of California Berkeley, 1950 University Avenue, Suite 460, Berkeley, CA, 94720, USA.
  • Ma X; School of Public Health, University of California Berkeley, 1950 University Avenue, Suite 460, Berkeley, CA, 94720, USA.
Nat Commun ; 9(1): 286, 2018 01 18.
Article en En | MEDLINE | ID: mdl-29348612
ABSTRACT
Childhood acute lymphoblastic leukemia (ALL) (age 0-14 years) is 20% more common in Latino Americans than non-Latino whites. We conduct a genome-wide association study in a large sample of 3263 Californian children with ALL (including 1949 of Latino heritage) and 3506 controls matched on month and year of birth, sex, and ethnicity, and an additional 12,471 controls from the Kaiser Resource for Genetic Epidemiology Research on Aging Cohort. Replication of the strongest genetic associations is performed in two independent datasets from the Children's Oncology Group and the California Childhood Leukemia Study. Here we identify new risk loci on 17q12 near IKZF3/ZPBP2/GSDMB/ORMDL3, a locus encompassing a transcription factor important for lymphocyte development (IKZF3), and at an 8q24 region known for structural contacts with the MYC oncogene. These new risk loci may impact gene expression via local (four 17q12 genes) or long-range (8q24) interactions, affecting function of well-characterized hematopoietic and growth-regulation pathways.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 8 / Cromosomas Humanos Par 17 / Predisposición Genética a la Enfermedad / Leucemia-Linfoma Linfoblástico de Células Precursoras / Estudio de Asociación del Genoma Completo Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: America do norte Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 8 / Cromosomas Humanos Par 17 / Predisposición Genética a la Enfermedad / Leucemia-Linfoma Linfoblástico de Células Precursoras / Estudio de Asociación del Genoma Completo Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: America do norte Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos