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GWAS of epigenetic aging rates in blood reveals a critical role for TERT.
Lu, Ake T; Xue, Luting; Salfati, Elias L; Chen, Brian H; Ferrucci, Luigi; Levy, Daniel; Joehanes, Roby; Murabito, Joanne M; Kiel, Douglas P; Tsai, Pei-Chien; Yet, Idil; Bell, Jordana T; Mangino, Massimo; Tanaka, Toshiko; McRae, Allan F; Marioni, Riccardo E; Visscher, Peter M; Wray, Naomi R; Deary, Ian J; Levine, Morgan E; Quach, Austin; Assimes, Themistocles; Tsao, Philip S; Absher, Devin; Stewart, James D; Li, Yun; Reiner, Alex P; Hou, Lifang; Baccarelli, Andrea A; Whitsel, Eric A; Aviv, Abraham; Cardona, Alexia; Day, Felix R; Wareham, Nicholas J; Perry, John R B; Ong, Ken K; Raj, Kenneth; Lunetta, Kathryn L; Horvath, Steve.
Afiliación
  • Lu AT; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Xue L; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
  • Salfati EL; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Chen BH; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Ferrucci L; National Heart, Lung and Blood Institute, Bethesda, MD, 20824-0105, USA.
  • Levy D; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Joehanes R; National Heart, Lung and Blood Institute, Bethesda, MD, 20824-0105, USA.
  • Murabito JM; National Heart, Lung and Blood Institute, Bethesda, MD, 20824-0105, USA.
  • Kiel DP; Department of Medicine, Section of General Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
  • Tsai PC; Institute for Aging Research, Hebrew SeniorLife, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, 02215, USA.
  • Yet I; Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
  • Bell JT; Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
  • Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
  • Tanaka T; Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
  • McRae AF; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Marioni RE; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.
  • Visscher PM; Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.
  • Wray NR; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.
  • Deary IJ; Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
  • Levine ME; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Quach A; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.
  • Assimes T; Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.
  • Tsao PS; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.
  • Absher D; Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.
  • Stewart JD; Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
  • Li Y; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Reiner AP; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Hou L; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Baccarelli AA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Whitsel EA; VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
  • Aviv A; HudsonAlpha Institute for Biotechnology, Huntsville, AL, 35806, USA.
  • Cardona A; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Day FR; Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Wareham NJ; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Perry JRB; Fred Hutchinson Cancer Research Center Box 358080, WHI Clinical Coordinating Ctr/Public Health Sciences M3-A4, Seattle, WA, 98109, USA.
  • Ong KK; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Chicago, Evanston, IL, 60611, USA.
  • Raj K; Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University Chicago, Evanston, IL, 60611, USA.
  • Lunetta KL; Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences Epidemiology, Columbia University Mailman School of Public Health, New York, NY, 10032, USA.
  • Horvath S; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.
Nat Commun ; 9(1): 387, 2018 01 26.
Article en En | MEDLINE | ID: mdl-29374233
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Telomerasa / Metilación de ADN / Epigénesis Genética Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Telomerasa / Metilación de ADN / Epigénesis Genética Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos