Detection and quantification of phenethylamines in sports dietary supplements by NMR approach.
J Pharm Biomed Anal
; 151: 347-355, 2018 Mar 20.
Article
en En
| MEDLINE
| ID: mdl-29413984
ABSTRACT
Phenethylamines (PEAs) are popular substances found in weight-loss and sports nutrition supplements. They are generally pharmacologically active and primarily affect the sympathetic nervous system. Many PEAs are synthetic chemicals and are on the prohibited list of the World Anti-Doping Agency. In this study, nuclear magnetic resonance (NMR) spectroscopy was applied to detect and identify the presence of PEAs in sports dietary supplements without the need for chromatographic separation or pre-knowledge on formulation. Eight PEAs, viz. phenethylamine, synephrine, oxilofrine, hordenine, ß-methylphenethylamine, N-methyltyramine, octopamine and deterenol, were identified from 32 dietary supplements sold in the US market. Furthermore, a quantitative NMR method was developed and validated for simultaneous determination of the concentrations of the PEAs. The study demonstrated that NMR could be a potential tool to monitor and detect PEAs or other ingredients in dietary supplements.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenetilaminas
/
Fitosteroles
/
Diosgenina
/
Doping en los Deportes
/
Sustancias para Mejorar el Rendimiento
/
Espectroscopía de Protones por Resonancia Magnética
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos