Domino Aryne Annulation via a Nucleophilic-Ene Process.
J Am Chem Soc
; 140(10): 3555-3559, 2018 03 14.
Article
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| MEDLINE
| ID: mdl-29421868
ABSTRACT
1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic-ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.
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01-internacional
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MEDLINE
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En
Revista:
J Am Chem Soc
Año:
2018
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Article