Domino Aryne Annulation via a Nucleophilic-Ene Process.

Xu, Hai; He, Jia; Shi, Jiarong; Tan, Liang; Qiu, Dachuan; Luo, Xiaohua; Li, Yang

Xu, Hai; He, Jia; Shi, Jiarong; Tan, Liang; Qiu, Dachuan; Luo, Xiaohua; Li, Yang.

Afiliación

Xu H; School of Chemistry and Chemical Engineering , Chongqing University , 174 Shazheng Street , Chongqing 400030 , P. R. China.
He J; School of Chemistry and Chemical Engineering , Chongqing University , 174 Shazheng Street , Chongqing 400030 , P. R. China.
Shi J; School of Chemistry and Chemical Engineering , Chongqing University , 174 Shazheng Street , Chongqing 400030 , P. R. China.
Tan L; School of Chemistry and Chemical Engineering , Chongqing University , 174 Shazheng Street , Chongqing 400030 , P. R. China.
Qiu D; School of Chemistry and Chemical Engineering , Chongqing University , 174 Shazheng Street , Chongqing 400030 , P. R. China.
Luo X; School of Chemistry and Chemical Engineering , Chongqing University , 174 Shazheng Street , Chongqing 400030 , P. R. China.
Li Y; School of Chemistry and Chemical Engineering , Chongqing University , 174 Shazheng Street , Chongqing 400030 , P. R. China.

J Am Chem Soc ; 140(10): 3555-3559, 2018 03 14.

Article en En | MEDLINE | ID: mdl-29421868

ABSTRACT

ABSTRACT

1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic-ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2018 Tipo del documento: Article