Influences of the vehicle in the spreading and release of betamethasone.
Ther Deliv
; 9(3): 177-184, 2018 02 01.
Article
en En
| MEDLINE
| ID: mdl-29424289
ABSTRACT
AIM:
We compared the performances of two different commercial products both based on betamethasone and an antibiotic but using different pharmaceutical vehicles a polymer and lipid-enriched cream and a conventional oil-in-water emulsion.METHODOLOGY:
Evaluation was conducted on a reconstructed human epidermis model. Moreover, skin barrier properties and cutaneous hydration of the two vehicles were evaluated on 20 human healthy volunteers.RESULTS:
Overall, the polymer and lipid-enriched formulation works as a film-forming product that retains the therapeutic agent for a long time, ensuring its penetration and absorption through the skin, and promoting skin hydration.CONCLUSION:
The above characteristics are useful in the clinical setting, especially in the context of eczematous diseases with a strong xerotic component.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Betametasona
/
Fármacos Dermatológicos
/
Composición de Medicamentos
/
Eccema
/
Antibacterianos
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Ther Deliv
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia