Increased plasma nesfatin-1 levels may be associated with corticosterone, IL-6, and CRP levels in patients with major depressive disorder.
Clin Chim Acta
; 480: 107-111, 2018 May.
Article
en En
| MEDLINE
| ID: mdl-29427582
ABSTRACT
OBJECTIVES:
The aim of the present study was to evaluate the plasma nesfatin-1, corticosterone, and inflammatory cytokine (IL-6, CRP, and TNF-α) concentrations cross-sectionally in patients with major depressive disorder.METHODS:
Subjects in the patient group were randomly selected from the Anhui Mental Health Center, and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index. The Hamilton Depression Rating Scale (HAM-D) was used to evaluate both groups. ELISAs were used for the measurement of plasma nesfatin-1, corticosterone, IL-6, CRP, and TNF-α levels.RESULTS:
The HAM-D scores and average nesfatin-1, corticosterone, IL-6, and CRP levels were significantly higher in patients with major depressive disorder than those in the control group. Positive correlation was found between nesfatin-1 and corticosterone (râ¯=â¯0.305, Pâ¯=â¯0.007), IL-6 (râ¯=â¯0.333, Pâ¯=â¯0.003), and CRP (râ¯=â¯0.244, Pâ¯=â¯0.034) concentrations.CONCLUSIONS:
Increased plasma nesfatin-1 levels may be associated with corticosterone, IL-6, and CRP levels in patients with major depressive disorder.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al Calcio
/
Proteína C-Reactiva
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Corticosterona
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Interleucina-6
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Trastorno Depresivo Mayor
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Proteínas de Unión al ADN
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Proteínas del Tejido Nervioso
Tipo de estudio:
Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Chim Acta
Año:
2018
Tipo del documento:
Article
País de afiliación:
China