Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation.
Front Neuroendocrinol
; 49: 124-145, 2018 04.
Article
en En
| MEDLINE
| ID: mdl-29428549
Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors were identified as mineralocorticoid receptors (MRs) that are involved in appraisal processes, choice of coping style, encoding and retrieval. The MR-mediated actions on cognition are complemented by slower actions via glucocorticoid receptors (GRs) on contextualization, rationalization and memory storage of the experience. These sequential phases in cognitive performance depend on synaptic metaplasticity that is regulated by coordinate MR- and GR activation. The receptor activation includes recruitment of coregulators and transcription factors as determinants of context-dependent specificity in steroid action; they can be modulated by genetic variation and (early) experience. Interestingly, inflammatory responses to damage seem to be governed by a similarly balanced MR:GR-mediated action as the initiating, terminating and priming mechanisms involved in stress-adaptation. We conclude with five questions challenging the MR:GR balance hypothesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Psicológico
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Receptores de Glucocorticoides
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Receptores de Mineralocorticoides
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Disfunción Cognitiva
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Hipocampo
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Amígdala del Cerebelo
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Inflamación
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Plasticidad Neuronal
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Front Neuroendocrinol
Año:
2018
Tipo del documento:
Article
Pais de publicación:
Estados Unidos