Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics.
ACS Chem Biol
; 13(4): 951-957, 2018 04 20.
Article
en En
| MEDLINE
| ID: mdl-29439566
ABSTRACT
Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain thioether cross-links formed by lanthionine and methyllanthionine residues. They exert potent antimicrobial activity against Gram-positive bacteria. We herein report production of analogues of two lantibiotics, lacticin 481 and nisin, that contain nonproteinogenic amino acids using two different strategies involving amber stop codon suppression technology. These methods complement recent alternative approaches to incorporate nonproteinogenic amino acids into lantibiotics.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacteriocinas
/
Aminoácidos
/
Antibacterianos
Idioma:
En
Revista:
ACS Chem Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos