Reconstitution of composite actin and keratin networks in vesicles.
Soft Matter
; 14(10): 1897-1902, 2018 Mar 07.
Article
en En
| MEDLINE
| ID: mdl-29464258
ABSTRACT
Although cytoskeletal networks are interpenetrating and interacting in living cells, very little is understood as to the effect their interaction has on their properties. Here, as a step towards elucidating the synergistic cellular role of these structural proteins, we investigate isolated keratin and actin composites and show how the in vitro network formation of keratin influences the properties of actin networks and vice versa. By encapsulating purified composite networks into vesicles and separating the time scales of network formation we are able to demonstrate that the actin network stabilizes keratin networks by providing an elastic resistance to their collapse in vitro.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Actinas
/
Queratinas
Límite:
Humans
Idioma:
En
Revista:
Soft Matter
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania