Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke.
Int J Neurosci
; 128(10): 966-974, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-29490535
ABSTRACT
BACKGROUND:
Mirror therapy (MT) is becoming an alternative rehabilitation strategy for various conditions, including stroke. Although recent studies suggest the positive benefit of MT in chronic stroke motor recovery, little is known about its neural mechanisms.PURPOSE:
To identify functional brain changes induced by a single MT intervention in ischemic stroke survivors, assessed by both transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI). MATERIALS ANDMETHODS:
TMS and fMRI were used to investigate 15 stroke survivors immediately before and after a single 30-min MT session.RESULTS:
We found statistically significant increase in post-MT motor evoked potential (MEP) amplitude (increased excitability) from the affected primary motor cortex (M1), when compared to pre-MT MEP. Post-MT fMRI maps were associated with a more organized and constrained pattern, with a more focal M1 activity within the affected hemisphere after MT, limited to the cortical area of hand representation. Furthermore, we find a change in the balance of M1 activity toward the affected hemisphere. In addition, significant correlation was found between decreased fMRI ß-values and increased MEP amplitude post-MT, in the affected hemisphere.CONCLUSION:
Our study suggests that a single MT intervention in stroke survivors is related to increased MEP of the affected limb, and a more constrained activity of the affected M1, as if activity had become more constrained and limited to the affected hemisphere.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Isquemia Encefálica
/
Evaluación de Resultado en la Atención de Salud
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Potenciales Evocados Motores
/
Accidente Cerebrovascular
/
Extremidad Superior
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Rehabilitación de Accidente Cerebrovascular
/
Corteza Motora
Tipo de estudio:
Etiology_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Neurosci
Año:
2018
Tipo del documento:
Article
País de afiliación:
Brasil