Utility of shear-wave elastography to differentiate low from advanced degrees of liver fibrosis in patients with hepatitis C virus infection of native and transplant livers.
J Clin Ultrasound
; 46(5): 311-318, 2018 Jun.
Article
en En
| MEDLINE
| ID: mdl-29508406
ABSTRACT
OBJECTIVE:
To determine the accuracy of shear-wave elastography (SWE) to differentiate low from advanced degrees of liver fibrosis in hepatitis C patients. MATERIAL &METHOD:
Consented native/transplant hepatitis C patients underwent SWE using a C1-6 MHz transducer before ultrasound (US)-guided liver biopsy. Five interpretable SWE samples were obtained from the right lobe of the liver immediately before US-guided random biopsy of the right lobe. Average kilopascal (kPa) values were compared to the meta-analysis of histological data in viral hepatitis (METAVIR) fibrosis grading. SWE values were correlated with the degree of inflammation and fatty infiltration.RESULTS:
Study population consisted of 115 patients (63 with transplant, and 52 with native liver) including 29 women and 86 men, with a mean ± SD age of 56 ± 8.7 years. Mean ± SD SWE values were 7.9 ± 3 kPa in 83 patients with METAVIR scores of 0-2 and 13.2 ± 5.9 kPa in 32 patients with METAVIR scores of 3 or 4 (P < .001). Area under curve (AUC) of a Receiver Operating Characteristics curve for advanced degrees of fibrosis was 0.81 (95% CI 0.71, 0.90) (P < .001). AUCs of transplant versus native livers (0.78 [CI0.62, 0.94] versus 0.85 [CI 0.73, 0.96]), degree of inflammation (0.81 [CI 0.65, 0.97] versus 0.72 [0.56, 0.88]), or degree of fat deposition (0.81 [CI0.70, 0.92] versus 0.80 [CI0.61, 1]) were not statistically different (P > .05). for kPa threshold of SWE value of 10.67 kPa to differentiate advanced from low degree of fibrosis had a sensitivity of 59% (CI 41%-76%) and specificity of 90% (CI 82%-96%).CONCLUSION:
Liver stiffness evaluated by SWE can differentiate low from advanced liver fibrosis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Hígado
/
Hepatitis C
/
Diagnóstico por Imagen de Elasticidad
/
Cirrosis Hepática
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Ultrasound
Año:
2018
Tipo del documento:
Article
País de afiliación:
Canadá