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Maternal and developmental toxicity of the hallucinogenic plant-based beverage ayahuasca in rats.
da Motta, Luciana Gueiros; de Morais, Juliana Alves; Tavares, Ana Carolina A M; Vianna, Leonora Maciel Sousa; Mortari, Marcia Renata; Amorim, Rivadávio Fernandes Batista; Carvalho, Rosângela R; Paumgartten, Francisco José R; Pic-Taylor, Aline; Caldas, Eloisa Dutra.
Afiliación
  • da Motta LG; Laboratory of Toxicology, Faculty of Health Sciences, University of Brasilia, Brasilia, DF, Brazil.
  • de Morais JA; Laboratory of Embryology and Developmental Biology, Department of Genetic and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, DF, Brazil.
  • Tavares ACAM; Laboratory of Toxicology, Faculty of Health Sciences, University of Brasilia, Brasilia, DF, Brazil.
  • Vianna LMS; Department of Pathology, School of Medicine, University of Brasilia, Brasilia, DF, Brazil.
  • Mortari MR; Laboratory of Neuropharmacology, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia, DF, Brazil.
  • Amorim RFB; Department of Pathology, School of Medicine, University of Brasilia, Brasilia, DF, Brazil.
  • Carvalho RR; Laboratory of Environmental Toxicology, National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
  • Paumgartten FJR; Laboratory of Environmental Toxicology, National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
  • Pic-Taylor A; Laboratory of Embryology and Developmental Biology, Department of Genetic and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, DF, Brazil.
  • Caldas ED; Laboratory of Toxicology, Faculty of Health Sciences, University of Brasilia, Brasilia, DF, Brazil. Electronic address: eloisa@unb.br.
Reprod Toxicol ; 77: 143-153, 2018 04.
Article en En | MEDLINE | ID: mdl-29522798
Rats were treated orally with ayahuasca (AYA) on gestation days (GD) 6-20 at doses corresponding to one-(1X) to eight-fold (8X) the average dose taken by a human adult in a religious ritual, and the pregnancy outcome evaluated on GD21. Rats treated with 4X and 8X doses died during the treatment period (44 and 52%), and those that survived showed kidney injury. Rats surviving the 8X dose showed neuronal loss in hippocampal regions and in the raphe nuclei, and those from the 2X dose neuronal loss in CA1. Delayed intrauterine growth, induced embryo deaths and increased occurrence of foetal anomalies were observed at the 8X dose. At non-lethal doses, AYA enhanced embryolethality and the incidence of foetal soft-tissue and skeleton anomalies. This study suggested that AYA is developmentally toxic and that its daily use by pregnant women may pose risks for the conceptus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Teratógenos / Bebidas / Preparaciones de Plantas / Banisteriopsis / Alucinógenos Límite: Animals / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Teratógenos / Bebidas / Preparaciones de Plantas / Banisteriopsis / Alucinógenos Límite: Animals / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos