Calcium carbonate-methylene blue nanohybrids for photodynamic therapy and ultrasound imaging.

Fan, Weili; Qi, Yu; Wang, Ranran; Xu, Chen; Zhao, Nana; Xu, Fu-Jian

Fan, Weili; Qi, Yu; Wang, Ranran; Xu, Chen; Zhao, Nana; Xu, Fu-Jian.

Afiliación

Fan W; Key Laboratory of Carbon Fiber and Functional Polymers (Beijing University of Chemical Technology), Ministry of Education, Beijing, China.
Qi Y; Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
Wang R; Key Laboratory of Carbon Fiber and Functional Polymers (Beijing University of Chemical Technology), Ministry of Education, Beijing, China.
Xu C; Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
Zhao N; Key Laboratory of Carbon Fiber and Functional Polymers (Beijing University of Chemical Technology), Ministry of Education, Beijing, China.
Xu FJ; Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.

Sci China Life Sci ; 61(4): 483-491, 2018 04.

Article en En | MEDLINE | ID: mdl-29546670

ABSTRACT

ABSTRACT

Photodynamic therapy plays an important role in cancer treatment. In this work, methylene blue (MB)-embedded calcium carbonate nanorods (CaCO3-MB NRs) have been synthesized for pH-responsive photodynamic therapy and ultrasound imaging. The morphology of CaCO3-MB NRs can be controlled by modulating the concentration of Na2CO3 aqueous solution. The generation of effective reactive oxygen species (ROS) were confirmed by 1,3-diphenylisobenzofuran (DPBF) probe. Both photodynamic therapy performance and echogenic performance of CaCO3-MB NRs were investigated to confirm the feasibility of CaCO3-MB nanohybrids for ultrasound image-guided photodynamic therapy.

Asunto(s)

Carbonato de Calcio/uso terapéutico; Azul de Metileno/uso terapéutico; Nanoestructuras/uso terapéutico; Neoplasias/terapia; Fotoquimioterapia/métodos; Nanomedicina Teranóstica/métodos; Ultrasonografía/métodos; Carbonato de Calcio/química; Carbonato de Calcio/farmacología; Dióxido de Carbono; Supervivencia Celular/efectos de los fármacos; Supervivencia Celular/efectos de la radiación; Células HeLa; Humanos; Concentración de Iones de Hidrógeno; Azul de Metileno/química; Azul de Metileno/farmacología; Modelos Químicos; Nanoestructuras/química; Nanoestructuras/ultraestructura; Tamaño de la Partícula; Fármacos Fotosensibilizantes/química; Fármacos Fotosensibilizantes/uso terapéutico; Oxígeno Singlete/análisis; Oxígeno Singlete/efectos de la radiación; Agua/química

Palabras clave

CaCO3-MB NRs; degradation; pH-responsive; photodynamic therapy; ultrasound imaging

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Carbonato de Calcio / Ultrasonografía / Nanoestructuras / Nanomedicina Teranóstica / Azul de Metileno / Neoplasias Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Sci China Life Sci Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: China

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