Different concentration of human cord blood HMGB1 according to delivery and labour: A pilot study.
Cytokine
; 108: 53-56, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-29571040
ABSTRACT
OBJECTIVE:
Oxidative stress is involved in several maternal conditions characterized both by an increase in free radicals synthesis and a parallel decrease in the antioxidant activity. Parturition induces considerable oxidative stress and many inflammatory mediators, among which HMGB1, are involved from the beginning of pregnancy to the birth of the infant. We evaluated serum cord blood HMGB1 levels in a population of neonates to investigate correlation with mode of delivery, as well as the influence of labour. SETTING AND PATIENTS The study subjects were 325 neonates delivered at University Hospital "G. Martino" of Messina over an 18-month period. Following cord separation, venous blood sampling was performed on umbelical cords.RESULTS:
In the cord venous blood, we found HMGB1 values significantly more elevated in spontaneous vaginal group when compared to elective or emergency caesarean section group. Regarding labour, umbilical cord venous blood HMGB1 levels were significantly higher in the spontaneous and induced labour group, compared to non-labouring women.CONCLUSION:
These results could highlight a possible role of HMGB1 during birth time related to mode of delivery and labour.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trabajo de Parto
/
Proteína HMGB1
/
Sangre Fetal
Límite:
Adult
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Female
/
Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Cytokine
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2018
Tipo del documento:
Article