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Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist.
Nuhn, Lutz; Van Hoecke, Lien; Deswarte, Kim; Schepens, Bert; Li, Yupeng; Lambrecht, Bart N; De Koker, Stefaan; David, Sunil A; Saelens, Xavier; De Geest, Bruno G.
Afiliación
  • Nuhn L; Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium; Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
  • Van Hoecke L; VIB-UGent Center for Medical Biotechnology, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Ghent, Belgium.
  • Deswarte K; VIB-UGent Center for Inflammation Research, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium; Department of Respiratory Medicine, University Hospital Ghent, 9000 Ghent, Belgium.
  • Schepens B; VIB-UGent Center for Medical Biotechnology, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Ghent, Belgium.
  • Li Y; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
  • Lambrecht BN; VIB-UGent Center for Inflammation Research, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium; Department of Respiratory Medicine, University Hospital Ghent, 9000 Ghent, Belgium.
  • De Koker S; VIB-UGent Center for Medical Biotechnology, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Ghent, Belgium.
  • David SA; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
  • Saelens X; VIB-UGent Center for Medical Biotechnology, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Ghent, Belgium.
  • De Geest BG; Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: br.degeest@ugent.be.
Biomaterials ; 178: 643-651, 2018 09.
Article en En | MEDLINE | ID: mdl-29573820
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Polietilenglicoles / Polietileneimina / Quinolinas / Vacunas Virales / Adyuvantes Inmunológicos / Receptor Toll-Like 7 / Receptor Toll-Like 8 / Imidazoles Límite: Animals Idioma: En Revista: Biomaterials Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Polietilenglicoles / Polietileneimina / Quinolinas / Vacunas Virales / Adyuvantes Inmunológicos / Receptor Toll-Like 7 / Receptor Toll-Like 8 / Imidazoles Límite: Animals Idioma: En Revista: Biomaterials Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos