Research progress in sRNAs and functional proteins in epididymosomes.
Yi Chuan
; 40(3): 197-206, 2018 Mar 20.
Article
en En
| MEDLINE
| ID: mdl-29576543
ABSTRACT
The semen quality is a basic and the most important indicator of male reproductive health. Mammalian spermatozoa undergo a series of complex structural and functional changes in the epididymis to mature and achieve fertilization capacity. Sperm cell maturation is mediated by a complex physiological process, which is synergistically regulated by a large number of transcription factors, hormones and other signaling molecules. In recent years, there is increasing evidence supporting the notion that functional proteins and sRNA (small RNAs) in epididymosomes participate in sperm maturation and fertilization process. In this review, we summarize the biological roles of functional proteins and two major sRNAs (tRNAs and miRNAs) in sperm maturation in epididymosomes, and provide some theoretical guidance and new ideas for treatments of low fertility, infertility and other reproductive diseases in men.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espermatozoides
/
ARN de Transferencia
/
MicroARNs
/
Epidídimo
Tipo de estudio:
Guideline
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Yi Chuan
Asunto de la revista:
GENETICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China