Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration.
Methods Enzymol
; 602: 289-298, 2018.
Article
en En
| MEDLINE
| ID: mdl-29588035
ABSTRACT
The existence of a barrier between anesthetic behavioral state transitions has been observed across phyla, but demonstrating that such a barrier exists and is not a pharmacokinetic artifact has not yet been possible in humans. Such an investigation requires temporally precise information regarding the brain concentration of anesthetic in order to demonstrate the specific pharmacokinetic-pharmacodynamic mismatch that is hysteresis. We propose a method to noninvasively determine brain tissue anesthetic concentration using computerized tomography and the radiopaque gaseous anesthetic xenon. Such a technique can be used to investigate pharmacokinetic-pharmacodynamic mismatches in humans.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Xenón
/
Encéfalo
/
Anestésicos por Inhalación
/
Escala de Evaluación de la Conducta
/
Anestesia
Límite:
Humans
Idioma:
En
Revista:
Methods Enzymol
Año:
2018
Tipo del documento:
Article