[Predictive factors of mortality in extremely preterm infants].
Zhonghua Er Ke Za Zhi
; 56(4): 274-278, 2018 Apr 02.
Article
en Zh
| MEDLINE
| ID: mdl-29614567
ABSTRACT
Objective:
To investigate the predictive factors of mortality in extremely preterm infants.Methods:
The retrospective case-control study was accomplished in the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University. A total of 268 extremely preterm infants seen from January 1, 1999 to December 31, 2015 were divided into survival group (192 cases) and death group (76 cases). The potential predictive factors of mortality were identified by univariate analysis, and then analyzed by multivariate unconditional Logistic regression analysis. The mortality and predictive factors were also compared between two time periods, which were January 1, 1999 to December 31, 2007 (65 cases) and January 1, 2008 to December 31, 2015 (203 cases).Results:
The median gestational age (GA) of extremely preterm infants was 27 weeks (23+3-27+6 weeks). The mortality was higher in infants with GA of 25-<26 weeks (OR=2.659, 95% CI 1.211-5.840) and<25 weeks (OR=10.029, 95% CI 3.266-30.792) compared to that in infants with GA> 26 weeks. From January 1, 2008 to December 31, 2015, the number of extremely preterm infants was increased significantly compared to the previous 9 years, while the mortality decreased significantly (OR=0.490, 95% CI 0.272-0.884). Multivariate unconditional Logistic regression analysis showed that GA below 25 weeks (OR=6.033, 95% CI 1.393-26.133), lower birth weight (OR=0.997, 95% CI 0.995-1.000), stage â ¢ necrotizing enterocolitis (NEC) (OR=15.907, 95% CI 3.613-70.033), grade â and â ¡ intraventricular hemorrhage (IVH) (OR=0.260, 95% CI 0.117-0.575) and dependence on invasive mechanical ventilation (OR=3.630, 95% CI 1.111-11.867) were predictive factors of mortality in extremely preterm infants.Conclusions:
GA below 25 weeks, lower birth weight, stage â ¢ NEC and dependence on invasive mechanical ventilation are risk factors of mortality in extremely preterm infants. But grade â andâ ¡ IVH is protective factor.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hemorragia Cerebral
/
Enterocolitis Necrotizante
/
Recien Nacido Extremadamente Prematuro
/
Enfermedades del Recién Nacido
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Infant
/
Newborn
Idioma:
Zh
Revista:
Zhonghua Er Ke Za Zhi
Año:
2018
Tipo del documento:
Article
País de afiliación:
China