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Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length.
Newcombe, Estella A; Ruff, Kiersten M; Sethi, Ashish; Ormsby, Angelique R; Ramdzan, Yasmin M; Fox, Archa; Purcell, Anthony W; Gooley, Paul R; Pappu, Rohit V; Hatters, Danny M.
Afiliación
  • Newcombe EA; Department of Biochemistry and Molecular Biology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia.
  • Ruff KM; Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St Louis, MO 63130, USA.
  • Sethi A; Department of Biochemistry and Molecular Biology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia.
  • Ormsby AR; Department of Biochemistry and Molecular Biology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia.
  • Ramdzan YM; Department of Biochemistry and Molecular Biology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia.
  • Fox A; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, WA 6009, Australia.
  • Purcell AW; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
  • Gooley PR; Department of Biochemistry and Molecular Biology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia.
  • Pappu RV; Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St Louis, MO 63130, USA. Electronic address: pappu@wustl.edu.
  • Hatters DM; Department of Biochemistry and Molecular Biology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia. Electronic address: dhatters@unimelb.edu.au.
J Mol Biol ; 430(10): 1442-1458, 2018 05 11.
Article en En | MEDLINE | ID: mdl-29627459
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Enfermedad de Huntington / Proteína Huntingtina / Mutación con Ganancia de Función Límite: Humans Idioma: En Revista: J Mol Biol Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Enfermedad de Huntington / Proteína Huntingtina / Mutación con Ganancia de Función Límite: Humans Idioma: En Revista: J Mol Biol Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos