Chromosome aberrations in mixed cultures of in vitro irradiated and unirradiated human lymphocytes.
Strahlenther Onkol
; 164(2): 108-10, 1988 Feb.
Article
en En
| MEDLINE
| ID: mdl-2964095
ABSTRACT
Human whole blood samples were exposed to different doses (1, 2, 4, 6 or 10 Gy) of gamma-radiation and mixed with different volumes of non-irradiated blood before culturing to simulate partial body irradiations. Chromosome aberrations were analysed and the frequency of dicentrics was found to be lower than expected, particularly when irradiated blood was mixed with large volumes of non-irradiated blood and after exposure to high radiation doses. For the mixtures of irradiated and unirradiated blood the deviation from the Poisson distribution depends on the respective proportions and on the doses. The results can be correlated to in vivo aberration frequencies in case of therapeutical treatments, but the yields of aberrations are generally underestimated in vitro.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Aberraciones Cromosómicas
Límite:
Humans
/
Male
Idioma:
En
Revista:
Strahlenther Onkol
Asunto de la revista:
NEOPLASIAS
/
RADIOTERAPIA
Año:
1988
Tipo del documento:
Article
País de afiliación:
Bélgica