Effects of dibromoacetic acid on murine spermatozoa and testis.
Reprod Med Biol
; 3(2): 85-93, 2004 Jun.
Article
en En
| MEDLINE
| ID: mdl-29657548
ABSTRACT
Background and Aims:
Bromoacetic acids are a by-product of water ozonation and dibromoacetic acid (DBAA) in particular, which is a by-product of disinfection, inhibits male reproductive functions. In order to understand its effects, the spermatozoa and testes of mice were exposed to DBAA.Methods:
Twelve-week-old ICR mice were exposed to 10 p.p.m. DBAA. They were examined in regards to effects on the weights of body, testis and epididymis, the histological changes of tesits and the protein expression in testis.Results:
Neither the bodyweight nor the weights of the testis and epididymis of the exposed mice was affected, but approximately 13% of spermatozoa obtained from the cauda epididymis were motile with a drop-shaped head, and structures resembling residual bodies were found in the testis. Moreover, the expression of two testis proteins was changed by exposure to DBAA.Conclusions:
It was likely that DBAA inhibited male reproductive functions by disturbance of spermatogenesis via change of protein expression. (Reprod Med Biol 2004; 3 85-93).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Reprod Med Biol
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón