Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

Lee, Ju Youn; Han, Seung Hoon; Park, Min Hee; Baek, Bosung; Song, Im-Sook; Choi, Min-Koo; Takuwa, Yoh; Ryu, Hoon; Kim, Seung Hyun; He, Xingxuan; Schuchman, Edward H; Bae, Jae-Sung; Jin, Hee Kyung

Lee, Ju Youn; Han, Seung Hoon; Park, Min Hee; Baek, Bosung; Song, Im-Sook; Choi, Min-Koo; Takuwa, Yoh; Ryu, Hoon; Kim, Seung Hyun; He, Xingxuan; Schuchman, Edward H; Bae, Jae-Sung; Jin, Hee Kyung.

Afiliación

Lee JY; Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, 41566, South Korea.
Han SH; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea.
Park MH; Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, 41944, South Korea.
Baek B; Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, 41566, South Korea.
Song IS; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea.
Choi MK; Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, 41944, South Korea.
Takuwa Y; Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, 41566, South Korea.
Ryu H; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea.
Kim SH; Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, 41944, South Korea.
He X; Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, 41566, South Korea.
Schuchman EH; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, South Korea.
Bae JS; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea.
Jin HK; College of Pharmacy, Dankook University, Cheon-an, 31116, South Korea.

Nat Commun ; 9(1): 1479, 2018 04 16.

Article en En | MEDLINE | ID: mdl-29662056

Asunto(s)

Acetilcoenzima A/metabolismo; Proteínas Adaptadoras Transductoras de Señales/metabolismo; Enfermedad de Alzheimer/enzimología; Ciclooxigenasa 2/metabolismo; Microglía/enzimología; Neuronas/enzimología; Proteínas Adaptadoras Transductoras de Señales/genética; Enfermedad de Alzheimer/genética; Enfermedad de Alzheimer/patología; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Animales; Encéfalo/enzimología; Encéfalo/patología; Ciclooxigenasa 2/genética; Modelos Animales de Enfermedad; Humanos; Lipoxinas/metabolismo; Masculino; Ratones; Ratones Transgénicos; Microglía/patología; Neuronas/patología; Fagocitosis; Presenilina-1/genética; Presenilina-1/metabolismo; Serina/metabolismo; Transgenes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetilcoenzima A / Microglía / Proteínas Adaptadoras Transductoras de Señales / Ciclooxigenasa 2 / Enfermedad de Alzheimer / Neuronas Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido

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