Human monoclonal antibodies against West Nile virus from Japanese encephalitis-vaccinated volunteers.
Antiviral Res
; 154: 58-65, 2018 06.
Article
en En
| MEDLINE
| ID: mdl-29665373
ABSTRACT
West Nile virus (WNV) is a positive-sense single-stranded RNA flavivirus belonging to the Japanese encephalitis virus (JEV) serocomplex of the Flaviviridae family and causes mosquito-borne infections. Although most human infection cases are asymptomatic, approximately one in 150 infected individuals develops meningoencephalitis, with a mortality rate of 4-14%. While the development of human neutralizing antibody therapeutics against WNV is strongly anticipated, WNV is difficult to study in conventional laboratories due to its high safety level requirement. In this study, we established fully human WNV-neutralizing monoclonal antibodies from the peripheral blood mononuclear cells of inactivated-JEV-vaccinated individuals, and these antibodies exhibited WNV neutralization both in vitro and in vivo. Our results demonstrate a new antibody cross-reactivity strategy to develop immunological therapeutic reagents for WNV and other JEV serotype viruses.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus del Nilo Occidental
/
Leucocitos Mononucleares
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Reacciones Cruzadas
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Vacunas contra la Encefalitis Japonesa
/
Anticuerpos Neutralizantes
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Anticuerpos Monoclonales
Límite:
Adult
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Animals
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Female
/
Humans
Idioma:
En
Revista:
Antiviral Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
Japón