Backbone 1H, 13C, and 15N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant.

Köhler, Christian; Carlström, Göran; Tångefjord, Stefan; Papavoine, Tineke; Lepistö, Matti; Edman, Karl; Akke, Mikael

Backbone ¹H, ¹³C, and ¹⁵N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant.

Köhler, Christian; Carlström, Göran; Tångefjord, Stefan; Papavoine, Tineke; Lepistö, Matti; Edman, Karl; Akke, Mikael.

Afiliación

Köhler C; Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Carlström G; Centre for Analysis and Synthesis, Department of Chemistry, Lund University, Lund, Sweden.
Tångefjord S; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Papavoine T; Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Lepistö M; Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Edman K; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden. karl.edman@astrazeneca.com.
Akke M; Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, Lund, Sweden. mikael.akke@bpc.lu.se.

Biomol NMR Assign ; 12(2): 263-268, 2018 10.

Article en En | MEDLINE | ID: mdl-29667121

Asunto(s)

Proteínas Mutantes/química; Mutación; Resonancia Magnética Nuclear Biomolecular; Receptores de Glucocorticoides/química; Receptores de Glucocorticoides/metabolismo; Humanos; Ligandos; Modelos Moleculares; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Unión Proteica; Dominios Proteicos; Receptores de Glucocorticoides/genética

Palabras clave

Allostery; Glucocorticoid receptor; Ligand binding; Nuclear receptors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Glucocorticoides / Resonancia Magnética Nuclear Biomolecular / Proteínas Mutantes / Mutación Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Biomol NMR Assign Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA NUCLEAR Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Países Bajos

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