Brown Adipose Tissue in Human Infants.
Handb Exp Pharmacol
; 251: 107-123, 2019.
Article
en En
| MEDLINE
| ID: mdl-29675580
ABSTRACT
Adapting to the cold extrauterine environment after birth is a great challenge for the newborn. Due to their high surface area-to-volume ratio, infants tend to lose more heat to the environment as compared to adults. In addition, human newborns lack sufficiently developed skeletal muscle mass to maintain body temperature through shivering thermogenesis, an important source of heat in cold-exposed adults. Evolution has provided humans and other placental mammals with brown adipose tissue (BAT), a tissue that converts chemically stored energy, in the form of fatty acids and glucose, into heat through non-shivering thermogenesis. The thermogenic activity of this tissue is significant for the human infant's ability to maintain a sufficiently high core body temperature. Although BAT has been studied in human infants for more than a century, the literature covering different aspects of the tissue is rather limited. The aim of this review is to summarize the literature and describe what is actually known about the tissue and its importance for early human life.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Temperatura Corporal
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Tejido Adiposo Pardo
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Músculo Esquelético
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Termogénesis
Límite:
Adult
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Animals
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Female
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Humans
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Infant
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Newborn
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Pregnancy
Idioma:
En
Revista:
Handb Exp Pharmacol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Suecia