Graphical Representation and Similarity Analysis of DNA Sequences Based on Trigonometric Functions.
Acta Biotheor
; 66(2): 113-133, 2018 Jun.
Article
en En
| MEDLINE
| ID: mdl-29675730
ABSTRACT
In this paper, we propose two four-base related 2D curves of DNA primary sequences (termed as F-B curves) and their corresponding single-base related 2D curves (termed as A-related, G-related, T-related and C-related curves). The constructions of these graphical curves are based on the assignments of individual base to four different sinusoidal (or tangent) functions; then by connecting all these points on these four sinusoidal (tangent) functions, we can get the F-B curves; similarly, by connecting the points on each of the four sinusoidal (tangent) functions, we get the single-base related 2D curves. The proposed 2D curves are all strictly non degenerate. Then, a 8-component characteristic vector is constructed to compare similarity among DNA sequences from different species based on a normalized geometrical centers of the proposed curves. As examples, we examine similarity among the coding sequences of the first exon of beta-globin gene from eleven species, similarity of cDNA sequences of beta-globin gene from eight species, and similarity of the whole mitochondrial genomes of 18 eutherian mammals. The experimental results well demonstrate the effectiveness of the proposed method.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Algoritmos
/
Gráficos por Computador
/
Análisis Numérico Asistido por Computador
/
ADN
/
Análisis de Secuencia de ADN
/
Globinas beta
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Biotheor
Año:
2018
Tipo del documento:
Article
País de afiliación:
China