Inhibition of p16<sup>INK4A</sup> to Rejuvenate Aging Human Cardiac Progenitor Cells via the Upregulation of Anti-oxidant and NF&#954;B Signal Pathways.

Khatiwala, Roshni V; Zhang, Shuning; Li, Xiuchun; Devejian, Neil; Bennett, Edward; Cai, Chuanxi

Inhibition of p16^INK4A to Rejuvenate Aging Human Cardiac Progenitor Cells via the Upregulation of Anti-oxidant and NFκB Signal Pathways.

Khatiwala, Roshni V; Zhang, Shuning; Li, Xiuchun; Devejian, Neil; Bennett, Edward; Cai, Chuanxi.

Afiliación

Khatiwala RV; Department of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, & Department of Medicine, Albany Medical College, Albany, NY, 12208, USA.
Zhang S; Department of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, & Department of Medicine, Albany Medical College, Albany, NY, 12208, USA.
Li X; Department of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, & Department of Medicine, Albany Medical College, Albany, NY, 12208, USA.
Devejian N; Division of Pediatric Cardiothoracic Surgery, Albany Medical Center, Albany, NY, 12208, USA.
Bennett E; Division of Cardiothoracic Surgery, Albany Medical Center, Albany, NY, 12208, USA.
Cai C; Department of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, & Department of Medicine, Albany Medical College, Albany, NY, 12208, USA. caic@amc.edu.

Stem Cell Rev Rep ; 14(4): 612-625, 2018 Aug.

Article en En | MEDLINE | ID: mdl-29675777

Asunto(s)

Antioxidantes/metabolismo; Senescencia Celular/genética; Inhibidor p16 de la Quinasa Dependiente de Ciclina/genética; FN-kappa B/metabolismo; Interferencia de ARN; Células Madre/metabolismo; Adulto; Anciano; Anciano de 80 o más Años; Células Cultivadas; Inhibidor p16 de la Quinasa Dependiente de Ciclina/metabolismo; Regulación de la Expresión Génica; Células HEK293; Atrios Cardíacos/citología; Humanos; Persona de Mediana Edad; Transducción de Señal/genética; Células Madre/citología; Regulación hacia Arriba

Palabras clave

Heart failure; Human cardiac stem/progenitor cells; Lentiviral knockdown; Myocardial infarction; cell rejuvenation; p16INK4A

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / FN-kappa B / Senescencia Celular / Inhibidor p16 de la Quinasa Dependiente de Ciclina / Interferencia de ARN / Antioxidantes Límite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Stem Cell Rev Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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