Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians.
Genomics
; 111(4): 737-743, 2019 07.
Article
en En
| MEDLINE
| ID: mdl-29678681
ABSTRACT
Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta-analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. No significant association was detected with the level of TgAb and TPOAb in the meta-analysis of GWAS or bivariate results for all individuals. The bivariate analysis in females only revealed a genome-wide significant association for the locus near GRIN3A (rs4457391, Pâ¯=â¯7.76â¯×â¯10-9). The same locus had borderline association with TPOAb levels in females (rs1935377, Pâ¯=â¯8.58â¯×â¯10-8). In conclusion, we identified a novel gender specific locus associated with TgAb and TPOAb levels. Our findings provide a novel insight into genetic and gender differences associated with thyroid antibodies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiroiditis Autoinmune
/
Proteínas de Unión al Calcio
/
Receptores de N-Metil-D-Aspartato
/
Polimorfismo de Nucleótido Simple
/
Proteínas de la Membrana
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Aspecto:
Determinantes_sociais_saude
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Genomics
Asunto de la revista:
GENETICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Croacia