Your browser doesn't support javascript.
loading
Micelle-Coated, Hierarchically Structured Nanofibers with Dual-Release Capability for Accelerated Wound Healing and Infection Control.
Albright, Victoria; Xu, Meng; Palanisamy, Anbazhagan; Cheng, Jun; Stack, Mary; Zhang, Beilu; Jayaraman, Arul; Sukhishvili, Svetlana A; Wang, Hongjun.
Afiliación
  • Albright V; Department of Materials Science and Engineering, Texas A&M University, 575 Ross Street, College Station, TX, 77843, USA.
  • Xu M; Department of Chemistry and Chemical Biology, Stevens Institute of Technology, 1 Castle Point on the Hudson, Hoboken, NJ, 07030, USA.
  • Palanisamy A; Department of Materials Science and Engineering, Texas A&M University, 575 Ross Street, College Station, TX, 77843, USA.
  • Cheng J; Department of Chemistry and Chemical Biology, Stevens Institute of Technology, 1 Castle Point on the Hudson, Hoboken, NJ, 07030, USA.
  • Stack M; Department of Biomedical Engineering, Stevens Institute of Technology, 1 Castle Point on the Hudson, Hoboken, NJ, 07030, USA.
  • Zhang B; Department of Chemistry and Chemical Biology, Stevens Institute of Technology, 1 Castle Point on the Hudson, Hoboken, NJ, 07030, USA.
  • Jayaraman A; Department of Chemical Engineering, Department of Biomedical Engineering, Texas A&M University, 0386 Spence Street, College Station, TX, 77843, USA.
  • Sukhishvili SA; Department of Materials Science and Engineering, Texas A&M University, 575 Ross Street, College Station, TX, 77843, USA.
  • Wang H; Department of Chemistry and Chemical Biology, Stevens Institute of Technology, 1 Castle Point on the Hudson, Hoboken, NJ, 07030, USA.
Adv Healthc Mater ; 7(11): e1800132, 2018 06.
Article en En | MEDLINE | ID: mdl-29683273
Tailoring nanofibrous matrices-a material with much promise for wound healing applications-to simultaneously mitigate bacterial colonization and stimulate wound closure of infected wounds is highly desirable. To that end, a dual-releasing, multiscale system of biodegradable electrospun nanofibers coated with biocompatible micellar nanocarriers is reported. For wound healing, transforming growth factor-ß1 is incorporated into polycaprolactone/collagen (PCL/Coll) nanofibers via electrospinning and the myofibroblastic differentiation of human dermal fibroblasts is locally stimulated. To prevent infection, biocompatible nanocarriers of polypeptide-based block copolymer micelles are deposited onto the surfaces of PCL/Coll nanofibers using tannic acid as a binding partner. Micelle-modified fibrous scaffolds are favorable for wound healing, not only supporting the attachment and spreading of fibroblasts comparable to those on noncoated nanofibers, but also significantly enhancing fibroblast migration. Micellar coatings can be loaded with gentamicin or clindamycin and exhibit antibacterial activity as measured by Petrifilm and zone of inhibition assays as well as time-dependent reduction of cellular counts of Staphylococcus aureus cultures. Moreover, delivery time of antibiotic dosage is tunable through the application of a novel modular approach. Altogether, this system holds great promise as an infection-mitigating, cell-stimulating, biodegradable skin graft for wound management and tissue engineering.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus / Cicatrización de Heridas / Materiales Biocompatibles Revestidos / Nanofibras / Micelas Límite: Humans Idioma: En Revista: Adv Healthc Mater Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus / Cicatrización de Heridas / Materiales Biocompatibles Revestidos / Nanofibras / Micelas Límite: Humans Idioma: En Revista: Adv Healthc Mater Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania