Coupling between Inclusions and Membranes at the Nanoscale.
Phys Rev Lett
; 120(12): 128104, 2018 Mar 23.
Article
en En
| MEDLINE
| ID: mdl-29694104
ABSTRACT
The activity of cell membrane inclusions (such as ion channels) is influenced by the host lipid membrane, to which they are elastically coupled. This coupling concerns the hydrophobic thickness of the bilayer (imposed by the length of the channel, as per the hydrophobic matching principle) but also its slope at the boundary of the inclusion. However, this parameter has never been measured so far. We combine small-angle x-ray scattering data and a complete elastic model to measure the slope for the model gramicidin channel and show that it is surprisingly steep in two membrane systems with very different elastic properties. This conclusion is confirmed and generalized by the comparison with recent results in the simulation literature and with conductivity measurements.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Gramicidina
/
Canales Iónicos
/
Lípidos de la Membrana
/
Modelos Biológicos
/
Modelos Químicos
Idioma:
En
Revista:
Phys Rev Lett
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia