Does exposure to PM10 decrease age at menarche?
Environ Int
; 117: 16-21, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-29704753
ABSTRACT
BACKGROUND:
There has been a consistent decrease in age at menarche in South Korea. A potential risk factor for early menarche is exposure to particulate matter (PM), because endocrine-disrupting compounds emitted into air from anthropogenic sources may be incorporated into PM. The objective of this study was to examine the association between pre-menarcheal exposure to PMâ¯≤â¯10⯵m in diameter (PM10) and age at menarche in adolescents of South Korea using Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2012 data.METHODS:
We used self-reported age at menarche of 639 girls aged 13-17â¯years in this study. The cut-off age for early menarche was set to 12â¯years. Based on each subject's address, 1-year, 2-year, and 3-year averages of annual mean PM10 concentrations (models 1-3) were linked to KNHANES. Models were adjusted for body mass index (BMI), city size, household income level, maternal age at menarche, and second-hand smoke exposure at home. SURVEYREG and SURVEYLOGISTIC procedures were used to address the complex survey design of KNHANES.RESULTS:
Overall analysis showed that exposure to PM10 has a significant effect on decreasing age at menarche. Multiple linear regression results suggested that each 1⯵g/m3 increase in 1-year, 2-year, 3-year averages of annual mean PM10 concentrations accelerated age at menarche by 0.046â¯years (95% CI -0.064, -0.027; pâ¯<â¯.0001), 0.038â¯years (95% CI -0.059, -0.018; pâ¯=â¯0.0003),and 0.031 years (95% CI -0.047, -0.015; pâ¯=â¯0.0002), respectively. Adjusted ORs for a 1⯵g/m3 increase in PM10 concentration were 1.08 (95% CI 1.04 -1.12) for model 1, 1.06 (95% CI 1.02 -1.10) for model 2, and 1.05 (95% CI 1.01 -1.09) for model 3.CONCLUSION:
Our findings suggest that elevated PM10 concentration can decrease age at menarche. This is the first study that investigates the association between exposure to PM10 and age at menarche using a nationally representative sample of Koreans.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Menarquia
/
Contaminantes Atmosféricos
/
Exposición a Riesgos Ambientales
/
Material Particulado
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Female
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Environ Int
Año:
2018
Tipo del documento:
Article