An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability.

Das, Manabendra; Du, Yang; Mortensen, Jonas S; Bae, Hyoung Eun; Byrne, Bernadette; Loland, Claus J; Kobilka, Brian K; Chae, Pil Seok

Das, Manabendra; Du, Yang; Mortensen, Jonas S; Bae, Hyoung Eun; Byrne, Bernadette; Loland, Claus J; Kobilka, Brian K; Chae, Pil Seok.

Afiliación

Das M; Department of Bionanotechnology, Hanyang University, Ansan, 155-88, Korea.
Du Y; Molecular and Cellular Physiology, Stanford, CA, 94305, USA.
Mortensen JS; Department of Neuroscience, University of Copenhagen, Copenhagen N, DK-2200, Denmark.
Bae HE; Department of Bionanotechnology, Hanyang University, Ansan, 155-88, Korea.
Byrne B; Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Loland CJ; Department of Neuroscience, University of Copenhagen, Copenhagen N, DK-2200, Denmark.
Kobilka BK; Molecular and Cellular Physiology, Stanford, CA, 94305, USA.
Chae PS; Department of Bionanotechnology, Hanyang University, Ansan, 155-88, Korea.

Chemistry ; 24(39): 9860-9868, 2018 Jul 11.

Article en En | MEDLINE | ID: mdl-29741269

Asunto(s)

Detergentes/química; Ácido Litocólico; Proteínas de la Membrana/química; Interacciones Hidrofóbicas e Hidrofílicas; Micelas; Estabilidad Proteica

Palabras clave

amphiphiles; membrane proteins; micelles; protein stabilization; protein structures

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Detergentes / Ácido Litocólico / Proteínas de la Membrana Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article Pais de publicación: Alemania

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