Candidate gene analysis of asthma in a population of Arab descent: a case-control study in Jordan.
Per Med
; 14(1): 51-61, 2017 01.
Article
en En
| MEDLINE
| ID: mdl-29749828
ABSTRACT
AIM:
To evaluate whether SNPs (n = 15) in ten candidate genes (ADRB2, ADH5, ARGI, CRHR1, STIP1, LTA4H, LTC4S, ALOX5, ABCC1 and OATP2B1) are associated with asthma in Jordanian population of Arab descent.METHODS:
A case-control study included 245 adult asthmatics and 249 controls.RESULTS:
Significant genetic association was identified at the rs2236647 (T/C) SNP in STIP1 and risk of asthma (p < 0.001). The C allele and CC genotype of this SNP were significantly higher in asthmatics compared with controls. The rs1141370 SNP (Val34Met) in ADRB2 is not polymorphic in our cohort.CONCLUSION:
The rs2236647 SNP could act as a reliable tool to identify individuals at risk of developing asthma and provision of early intervention in population of Arab descent.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asma
/
Proteínas de Choque Térmico
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Per Med
Año:
2017
Tipo del documento:
Article
País de afiliación:
Jordania