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Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.
Waszak, Sebastian M; Northcott, Paul A; Buchhalter, Ivo; Robinson, Giles W; Sutter, Christian; Groebner, Susanne; Grund, Kerstin B; Brugières, Laurence; Jones, David T W; Pajtler, Kristian W; Morrissy, A Sorana; Kool, Marcel; Sturm, Dominik; Chavez, Lukas; Ernst, Aurelie; Brabetz, Sebastian; Hain, Michael; Zichner, Thomas; Segura-Wang, Maia; Weischenfeldt, Joachim; Rausch, Tobias; Mardin, Balca R; Zhou, Xin; Baciu, Cristina; Lawerenz, Christian; Chan, Jennifer A; Varlet, Pascale; Guerrini-Rousseau, Lea; Fults, Daniel W; Grajkowska, Wieslawa; Hauser, Peter; Jabado, Nada; Ra, Young-Shin; Zitterbart, Karel; Shringarpure, Suyash S; De La Vega, Francisco M; Bustamante, Carlos D; Ng, Ho-Keung; Perry, Arie; MacDonald, Tobey J; Hernáiz Driever, Pablo; Bendel, Anne E; Bowers, Daniel C; McCowage, Geoffrey; Chintagumpala, Murali M; Cohn, Richard; Hassall, Timothy; Fleischhack, Gudrun; Eggen, Tone; Wesenberg, Finn.
Afiliación
  • Waszak SM; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
  • Northcott PA; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Buchhalter I; Division of Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany; Division of Applied Bioinformatics, German Cancer Research Center, Heidelberg, Germany.
  • Robinson GW; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Sutter C; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany.
  • Groebner S; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Grund KB; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany.
  • Brugières L; Department of Children and Adolescents Oncology, Gustave Roussy Cancer Campus, Villejuif, France.
  • Jones DTW; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany.
  • Pajtler KW; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germ
  • Morrissy AS; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
  • Kool M; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany.
  • Sturm D; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germ
  • Chavez L; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Ernst A; Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany.
  • Brabetz S; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germ
  • Hain M; Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany.
  • Zichner T; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
  • Segura-Wang M; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
  • Weischenfeldt J; Biotech Research and Innovation Centre, Copenhagen, Denmark; Finsen Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
  • Rausch T; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
  • Mardin BR; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
  • Zhou X; Department of Computational Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Baciu C; University Health Network-Toronto General Hospital, Toronto, ON, Canada.
  • Lawerenz C; Data Management Facility, German Cancer Research Center, Heidelberg, Germany.
  • Chan JA; Department of Pathology and Laboratory Medicine, Department of Oncology, and Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Varlet P; Department of Neuropathology, Sainte-Anne Hospital, Paris, France.
  • Guerrini-Rousseau L; Department of Children and Adolescents Oncology, Gustave Roussy Cancer Campus, Villejuif, France.
  • Fults DW; Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Grajkowska W; Department of Pathology, Children's Memorial Health Institute, Warsaw, Poland.
  • Hauser P; 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
  • Jabado N; Department of Pediatrics, McGill University, Montreal, QC, Canada.
  • Ra YS; Department of Neurosurgery, Asan Medical Center, Seoul, South Korea.
  • Zitterbart K; Department of Paediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
  • Shringarpure SS; Departments of Genetics and Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.
  • De La Vega FM; Departments of Genetics and Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.
  • Bustamante CD; Departments of Genetics and Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.
  • Ng HK; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Perry A; Division of Neuropathology, Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
  • MacDonald TJ; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, USA.
  • Hernáiz Driever P; Klinik für Pädiatrie mS Onkologie und Hämatologie, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
  • Bendel AE; Department of Pediatric Hematology and Oncology, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN, USA.
  • Bowers DC; Division of Pediatric Hematology-Oncology, University of Texas Southwestern Medical School, Dallas, TX, USA.
  • McCowage G; Department of Paediatric Oncology, The Children's Hospital at Westmead, Sydney, NSW, Australia.
  • Chintagumpala MM; Department of Pediatric Hematology and Oncology, Texas Children's Hospital, Houston, TX, USA.
  • Cohn R; Department of Paediatric Oncology, Sydney Children's Hospital, Sydney, NSW, Australia.
  • Hassall T; Department of Paediatric Oncology, Lady Cilento Children's Hospital, South Brisbane, QLD, Australia.
  • Fleischhack G; Pediatric Oncology and Hematology, Pediatrics III, University Hospital of Essen, Essen, Germany.
  • Eggen T; Cancer Registry of Norway, Oslo, Norway.
  • Wesenberg F; Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Cancer Registry of Norway, Oslo, Norway.
Lancet Oncol ; 19(6): 785-798, 2018 06.
Article en En | MEDLINE | ID: mdl-29753700
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Neoplasias Cerebelosas / Pruebas Genéticas / Mutación de Línea Germinal / Metilación de ADN / Meduloblastoma / Modelos Genéticos Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Neoplasias Cerebelosas / Pruebas Genéticas / Mutación de Línea Germinal / Metilación de ADN / Meduloblastoma / Modelos Genéticos Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido