Post-Extrasystolic Potentiation as a Predictor of Recovery of Left Ventricular Dysfunction After Radiofrequency Catheter Ablation.
JACC Clin Electrophysiol
; 3(11): 1283-1291, 2017 11.
Article
en En
| MEDLINE
| ID: mdl-29759625
ABSTRACT
OBJECTIVES:
This study hypothesizes that post-extrasystolic potentiation reflects left ventricle contractile reserve and therefore may predict an improvement of premature ventricular contraction (PVC)-induced cardiomyopathy after PVC ablation.BACKGROUND:
Post-extrasystolic potentiation is a physiologic phenomenon of blood pressure accentuation after a PVC beat.METHODS:
We performed a retrospective study of patients with a PVC burden of ≥10% PVC/24 h and left ventricular ejection fraction (LVEF) of <50% who underwent successful ablation between January 1, 2009, to June 30, 2015. Subjects were classified as having reversible (a final LVEF ≥50%) or irreversible (final LVEF <50%) LV dysfunction on a follow-up echocardiogram. A reference (control) group with ≥10% PVC but normal LV function was also identified.RESULTS:
Sixty-one patients (age 68 ± 11 years, 98% male) were studied 30 with preserved and 31 with reduced LVEF. During median follow-up of 9.4 months, the LVEF of 17 of 31 reduced EF patients improved (reversible) but 14 did not (irreversible). The post-PVC beat systolic blood pressure (SBP) (mm Hg) increase ranged from 12.1 in control subjects (LVEF >50%) to 11.5 in reversible patients to 5 in irreversible patients. In multivariate analysis, the independent predictors of reversible LV function were post-PVC SBP rise (odds ratio [OR] 4.61; 95% confidence interval [CI] 1.45 to 15.83 per 5-mm Hg increase; p < 0.001), post-PVC pulse pressure change (OR 5.2; 95% CI 2.3 to 18.6 per 5-mm Hg increase; p < 0.001), and PVC QRS duration (OR 2.78; 95% CI 1.63 to 10.94 per 10-ms increase; p < 0.001).CONCLUSIONS:
In patients with LV dysfunction and frequent PVC, post-PVC SBP accentuation may be a marker for subsequent recovery of LVEF after ablation in presumed PVC-induced cardiomyopathy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ablación por Catéter
/
Disfunción Ventricular Izquierda
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Complejos Prematuros Ventriculares
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
JACC Clin Electrophysiol
Año:
2017
Tipo del documento:
Article