ADAMTS13 deficiency and immunological abnormalities in patients with systemic sclerosis.
Postepy Dermatol Alergol
; 35(2): 182-184, 2018 Apr.
Article
en En
| MEDLINE
| ID: mdl-29760619
ABSTRACT
INTRODUCTION:
Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disorder characterized by immunological deviations and generalized microvascular damage.AIM:
To determine the serum level of the von Willebrand factor cleaving protease (ADAMTS13) in 39 SSc patients and healthy controls. MATERIAL ANDMETHODS:
ADAMTS13 serum level was determined in 39 SSc patients and 11 healthy controls. Complete history of the patients was recorded and thorough clinical, rheumatological, and dermatological examinations were performed.RESULTS:
The serum levels of ADAMTS13 were significantly lower in SSc than in normal controls (455.47 ±128 vs. 702.01 ±142 ng/ml, p < 0.00001). However significant correlations among serum ADAMTS 13 levels and organ changes were not found in SSc patients.CONCLUSIONS:
We demonstrate a decreased serum level of ADAMTS13 in SSc patients, which may contribute to the vessel microangiopathy observed in systemic sclerosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Postepy Dermatol Alergol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Polonia