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Aza-Macrocyclic Triphenylamine Ligands for G-Quadruplex Recognition.
Pont, Isabel; González-García, Jorge; Inclán, Mario; Reynolds, Matthew; Delgado-Pinar, Estefanía; Albelda, M Teresa; Vilar, Ramon; García-España, Enrique.
Afiliación
  • Pont I; Department of Inorganic Chemistry, Institute of Molecular Science, University of Valencia, Catedrático José Beltran 2, 46980, Paterna, Spain.
  • González-García J; Department of Chemistry, Imperial College London, London, SW7 2AZ, UK.
  • Inclán M; Department of Inorganic Chemistry, Institute of Molecular Science, University of Valencia, Catedrático José Beltran 2, 46980, Paterna, Spain.
  • Reynolds M; Department of Chemistry, Imperial College London, London, SW7 2AZ, UK.
  • Delgado-Pinar E; Department of Inorganic Chemistry, Institute of Molecular Science, University of Valencia, Catedrático José Beltran 2, 46980, Paterna, Spain.
  • Albelda MT; Department of Chemistry, Imperial College London, London, SW7 2AZ, UK.
  • Vilar R; Department of Inorganic Chemistry, Institute of Molecular Science, University of Valencia, Catedrático José Beltran 2, 46980, Paterna, Spain.
  • García-España E; Department of Inorganic Chemistry, Institute of Molecular Science, University of Valencia, Catedrático José Beltran 2, 46980, Paterna, Spain.
Chemistry ; 24(42): 10850-10858, 2018 Jul 25.
Article en En | MEDLINE | ID: mdl-29768679
ABSTRACT
A new series of triphenylamine-based ligands with one (TPA1PY), two (TPA2PY) or three pendant aza-macrocycle(s) (TPA3PY) has been synthesised and studied by means of pH-metric titrations, UV/Vis spectroscopy and fluorescence experiments. The affinity of these ligands for G-quadruplex (G4) DNA and the selectivity they show for G4s over duplex DNA were investigated by Förster resonance energy transfer (FRET) melting assays, fluorimetric titrations and circular dichroism spectroscopy. Interestingly, the interactions of the bi- and especially the tri-branched ligands with G4s lead to a very intense redshifted fluorescence emission band that may be associated with intermolecular aggregation between the molecule and DNA. This light-up effect allows the application of the ligands as fluorescence probes to selectively detect G4s.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: España