Enhanced cell growth on 3D graphene scaffolds implanted with nitrogen ions.
Biointerphases
; 13(4): 041001, 2018 05 16.
Article
en En
| MEDLINE
| ID: mdl-29768924
ABSTRACT
One of the key challenges in engineering tissues for cell-based therapies is developing biocompatible scaffold materials to direct cell behavior. In this paper, the cytocompatibilities of a flexible three-dimensional graphene scaffold (3D-G) and the same scaffold implanted with nitrogen ions (N+/3D-G) are compared using an in vitro assay based on 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The N+/3D-G samples were prepared from low-temperature hydrothermally synthesized flexible 3D-G by ion implantation and were found to display improved adhesion and proliferation of rat osteoblast and mouse fibroblast cells. In particular, the N+/3D-G sample with a nitrogen content of â¼10% showed the highest levels of cell viability and proliferation. The flexible N+/3D-G has potential applications as a biocompatible scaffold material that provides improved surface area and hydrophilic groups for cell growth and proliferation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoblastos
/
Materiales Biocompatibles
/
Supervivencia Celular
/
Andamios del Tejido
/
Fibroblastos
/
Grafito
/
Nitrógeno
Límite:
Animals
Idioma:
En
Revista:
Biointerphases
Asunto de la revista:
BIOTECNOLOGIA
/
ENGENHARIA BIOMEDICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China