The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress.
Cell
; 173(5): 1265-1279.e19, 2018 05 17.
Article
en En
| MEDLINE
| ID: mdl-29775595
ABSTRACT
Chronic social isolation causes severe psychological effects in humans, but their neural bases remain poorly understood. 2 weeks (but not 24 hr) of social isolation stress (SIS) caused multiple behavioral changes in mice and induced brain-wide upregulation of the neuropeptide tachykinin 2 (Tac2)/neurokinin B (NkB). Systemic administration of an Nk3R antagonist prevented virtually all of the behavioral effects of chronic SIS. Conversely, enhancing NkB expression and release phenocopied SIS in group-housed mice, promoting aggression and converting stimulus-locked defensive behaviors to persistent responses. Multiplexed analysis of Tac2/NkB function in multiple brain areas revealed dissociable, region-specific requirements for both the peptide and its receptor in different SIS-induced behavioral changes. Thus, Tac2 coordinates a pleiotropic brain state caused by SIS via a distributed mode of action. These data reveal the profound effects of prolonged social isolation on brain chemistry and function and suggest potential new therapeutic applications for Nk3R antagonists.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Precursores de Proteínas
/
Aislamiento Social
/
Estrés Psicológico
/
Encéfalo
/
Neuroquinina B
/
Taquicininas
Aspecto:
Determinantes_sociais_saude
Límite:
Animals
Idioma:
En
Revista:
Cell
Año:
2018
Tipo del documento:
Article