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Degradation of recombinant proteins by Chinese hamster ovary host cell proteases is prevented by matriptase-1 knockout.
Laux, Holger; Romand, Sandrine; Nuciforo, Sandro; Farady, Christopher J; Tapparel, Joel; Buechmann-Moeller, Stine; Sommer, Benjamin; Oakeley, Edward J; Bodendorf, Ursula.
Afiliación
  • Laux H; Integrated Biologics Profiling Unit, Novartis Pharma AG, Basel, Switzerland.
  • Romand S; Integrated Biologics Profiling Unit, Novartis Pharma AG, Basel, Switzerland.
  • Nuciforo S; Integrated Biologics Profiling Unit, Novartis Pharma AG, Basel, Switzerland.
  • Farady CJ; Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Tapparel J; Autoimmunity, Transplantation & Inflammatory Disease, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Buechmann-Moeller S; Early Phase Development, Novartis Pharma AG, Basel, Switzerland.
  • Sommer B; Autoimmunity, Transplantation & Inflammatory Disease, Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Oakeley EJ; Early Phase Development, Novartis Pharma AG, Basel, Switzerland.
  • Bodendorf U; Autoimmunity, Transplantation & Inflammatory Disease, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Biotechnol Bioeng ; 115(10): 2530-2540, 2018 10.
Article en En | MEDLINE | ID: mdl-29777593
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina Endopeptidasas / Técnicas de Silenciamiento del Gen / Ingeniería Celular / Proteolisis Límite: Animals / Humans Idioma: En Revista: Biotechnol Bioeng Año: 2018 Tipo del documento: Article País de afiliación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina Endopeptidasas / Técnicas de Silenciamiento del Gen / Ingeniería Celular / Proteolisis Límite: Animals / Humans Idioma: En Revista: Biotechnol Bioeng Año: 2018 Tipo del documento: Article País de afiliación: Suiza