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Modeling and MANOVA studies on toxicity and endocrine potential of packaging materials exposed to different extraction schemes.
Szczepanska, Natalia; Kudlak, Blazej; Tsakovski, Stefan; Yotova, Galina; Nedyalkova, Miroslava; Simeonov, Vasil; Dolega, Anna; Namiesnik, Jacek.
Afiliación
  • Szczepanska N; Department of Analytical Chemistry, Faculty of Chemistry, Gdansk University of Technology, 11/12 Narutowicza Str., Gdansk 80-233, Poland.
  • Kudlak B; Department of Analytical Chemistry, Faculty of Chemistry, Gdansk University of Technology, 11/12 Narutowicza Str., Gdansk 80-233, Poland. Electronic address: blakudla@pg.edu.pl.
  • Tsakovski S; Department of Analytical Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia, 1 James Bourchier Blvd, Sofia 1164, Bulgaria.
  • Yotova G; Department of Analytical Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia, 1 James Bourchier Blvd, Sofia 1164, Bulgaria.
  • Nedyalkova M; Chair of General and Inorganic Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia "St. Kl. Okhridski", 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria.
  • Simeonov V; Department of Analytical Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia, 1 James Bourchier Blvd, Sofia 1164, Bulgaria.
  • Dolega A; Department of Inorganic Chemistry, Faculty of Chemistry, Gdansk University of Technology, 11/12 Narutowicza Str., Gdansk 80-233, Poland.
  • Namiesnik J; Department of Analytical Chemistry, Faculty of Chemistry, Gdansk University of Technology, 11/12 Narutowicza Str., Gdansk 80-233, Poland.
Environ Res ; 165: 294-305, 2018 08.
Article en En | MEDLINE | ID: mdl-29777920
ABSTRACT
The stability of the linings of packaging that is in contact with the goods stored has been of major concern during decades of the development of packaging materials. In this work, an attempt was undertaken to assess the applicability of using two bioassays (Microtox® and XenoScreen YES/YAS) in estimating the stability of packaging (cans, caps, multilayer material) and the impact of their degradation on the toxicity of some simulated media. The assessment of the impact of packaging storage conditions (temperature, disinfection, preservation, extracting and washing solvents) was planned and performed with i) regression modeling of the experimental effects on the ecotoxicity readings, ii) ANOVA and MANOVA estimation of the experimental conditions as significant factors affecting the toxicity results and iii) FTIR analysis of the packages. It is shown that the effects of temperature and extraction solvents could be quantitatively assessed by the agreement between all methods applied. It can be stated that temperature and acidity as well as the alcohol content in the sensitive media have the greatest impact on the toxicity of the extract and thus on the stability of the internal lining and the extractability of xenobiotics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manejo de Especímenes / Xenobióticos / Pruebas de Toxicidad / Embalaje de Productos Tipo de estudio: Prognostic_studies Idioma: En Revista: Environ Res Año: 2018 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manejo de Especímenes / Xenobióticos / Pruebas de Toxicidad / Embalaje de Productos Tipo de estudio: Prognostic_studies Idioma: En Revista: Environ Res Año: 2018 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS