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The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review.
Monticelli, M; Zeppa, P; Zenga, F; Altieri, R; Mammi, M; Bertero, L; Castellano, I; Cassoni, P; Melcarne, A; La Rocca, G; Sabatino, G; Ducati, A; Garbossa, D.
Afiliación
  • Monticelli M; Neurosurgical Unit, Department of Neuroscience, University of Turin, Turin, Italy. Electronic address: mmonticelli89@gmail.com.
  • Zeppa P; Neurosurgical Unit, Department of Neuroscience, University of Turin, Turin, Italy.
  • Zenga F; Neurosurgical Unit, Department of Neuroscience, University of Turin, Turin, Italy.
  • Altieri R; Neurosurgical Unit, Department of Neuroscience, University of Turin, Turin, Italy.
  • Mammi M; Neurosurgical Unit, Department of Neuroscience, University of Turin, Turin, Italy.
  • Bertero L; Pathology Unit, Department of Medical Science, University of Turin, Turin, Italy.
  • Castellano I; Pathology Unit, Department of Medical Science, University of Turin, Turin, Italy.
  • Cassoni P; Pathology Unit, Department of Medical Science, University of Turin, Turin, Italy.
  • Melcarne A; Neurosurgical Unit, Department of Neuroscience, University of Turin, Turin, Italy.
  • La Rocca G; Institute of Neurosurgery, Catholic University of Rome, Agostino Gemelli Hospital, Rome, Italy.
  • Sabatino G; Institute of Neurosurgery, Catholic University of Rome, Agostino Gemelli Hospital, Rome, Italy.
  • Ducati A; Neurosurgical Unit, Department of Neuroscience, University of Turin, Turin, Italy.
  • Garbossa D; Neurosurgical Unit, Department of Neuroscience, University of Turin, Turin, Italy.
Clin Neurol Neurosurg ; 170: 120-126, 2018 07.
Article en En | MEDLINE | ID: mdl-29777944
ABSTRACT
Glioblastoma (GBM) is the most common glioma in adults, with incidence increasing by 3% per year. According to the World Health Organization Classification of Central Nervous System Tumors, GBM is considered a grade IV tumor due to its malignant behavior. The aim of this review is to summarize the main biological aspects of GBM. In particular, we focused our attention on those alterations which have been proven to have an impact on patients' outcome, mainly in terms of overall survival (OS), or on the tumor response to therapies. We have also analyzed the cellular biology and the interactions between GBM and the surrounding environment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Biomarcadores de Tumor / Glioblastoma / Manejo de la Enfermedad Límite: Humans Idioma: En Revista: Clin Neurol Neurosurg Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Biomarcadores de Tumor / Glioblastoma / Manejo de la Enfermedad Límite: Humans Idioma: En Revista: Clin Neurol Neurosurg Año: 2018 Tipo del documento: Article