Review of bioactive secondary metabolites from marine bryozoans in the progress of new drugs discovery.
Future Med Chem
; 10(12): 1497-1514, 2018 06 01.
Article
en En
| MEDLINE
| ID: mdl-29788787
Marine bryozoans play an important role for the discovery of novel bioactive compounds among marine organisms. In this review, we summarize 164 new secondary metabolites including macrocyclic lactones, sterols, alkaloids, sphingolipids and so forth from 24 marine bryozoans in the last two decades. The structural features, bioactivity, structure-activity relationship, mechanism and strategies to address the resupply of these scarce secondary metabolites are discussed. The structural and bioactive diversity of the secondary metabolites from marine bryozoans indicated the possibility of using these compounds, especially bryostatin 1 (1), bryostatin analog (BA1), alkaloids (50, 53, 127-128 and 134-139), sphingolipids sulfates (148 and 149) and sulfur-containing aromatic compound (160), as the starting points for new drug discovery.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esfingolípidos
/
Esteroles
/
Productos Biológicos
/
Briozoos
/
Alcaloides
/
Brioestatinas
/
Descubrimiento de Drogas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2018
Tipo del documento:
Article
Pais de publicación:
Reino Unido