Rapid Photoactuation of a DNA Nanostructure using an Internal Photocaged Trigger Strand.
Angew Chem Int Ed Engl
; 57(30): 9341-9345, 2018 07 20.
Article
en En
| MEDLINE
| ID: mdl-29790232
ABSTRACT
A reconfigurable DNA nano-tweezer is reported that can be switched between a closed and open state with a brief pulse of UV light. In its initial state, the tweezer is held shut using a hairpin with a single-stranded poly-A loop. Also incorporated in the structure is a poly-T trigger strand bearing seven photocaged residues. Upon illumination with 365â
nm light, the cages are removed and the trigger strand hybridizes to the loop, opening the tweezer and increasing the distance between its arms from 4 to 18â
nm. This intramolecular process is roughly 60 times faster than adding an external trigger strand, and provides a mechanism for the rapid interconversion of DNA nanostructures with light.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rayos Ultravioleta
/
ADN
/
Nanoestructuras
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos