Resveratrol prevents high-calorie diet-induced learning and memory dysfunction in juvenile C57BL/6J mice.
Neurol Res
; 40(8): 709-715, 2018 Aug.
Article
en En
| MEDLINE
| ID: mdl-29792387
ABSTRACT
OBJECTIVE:
Because resveratrol (RSV) has been shown to improve learning and memory, so we investigated the potential benefit of RSV on learning and memory deficits in juvenile mice fed with a HC diet and explored the molecular mechanisms underlying this process.METHODS:
Six-week-old C57BL/6J mice were divided into three different diet groups control, HC diet, and HC + RSV diet. Serum insulin and insulin-like growth factor 1 (IGF-1) levels were measured using enzyme-linked immunosorbent assays. Protein expression was examined by immunohistochemistry and western blotting.RESULTS:
Administration of RSV daily (30 mg/kg) prevented the HC diet-induced increase in juvenile animal body weight but did not improve any other physiological conditions, including fasting blood glucose and serum cholesterol, triglyceride, insulin, and IGF-1 levels. However, RSV did prevent learning and memory deficits in the HC group. Peroxisome proliferator-activated receptor gamma (PPARγ) was downregulated in the CA1 region of the hippocampus in both the HC and HC + RSV groups, but the reduction was significantly greater in the HC + RSV group (P < .01 compared with the HC group). Moreover, although the HC diet reduced the number of p16-positive neurons, the HC + RSV diet significantly upregulated p16 expression in the CA1 region of the hippocampus (P < .01 compared with the HC group).CONCLUSIONS:
RSV protected against learning and memory impairments in juvenile animals fed with a HC diet, possibly via upregulation of p16 or downregulation of PPARγ in the hippocampal CA1 region.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estilbenos
/
Nootrópicos
/
Dieta Alta en Grasa
/
Discapacidades para el Aprendizaje
/
Trastornos de la Memoria
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Neurol Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
China