Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment.
ASN Neuro
; 10: 1759091418777438, 2018.
Article
en En
| MEDLINE
| ID: mdl-29809058
ABSTRACT
Parkinson disease (PD) is the second most common neurodegenerative movement disorder. Pharmacological animal models are invaluable tools to study the pathological mechanisms of PD. Currently, invertebrate and vertebrate animal models have been developed by using several main neurotoxins, such as 6-hydroxydopamine, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, paraquat, and rotenone. These models achieve to some extent to reproduce the key features of PD, including motor defects, progressive loss of dopaminergic neurons in substantia nigra pars compacta, and the formation of Lewy bodies. In this review, we will highlight the pathogenic mechanisms of those neurotoxins and summarize different neurotoxic animal models with the hope to help researchers choose among them accurately and to promote the development of modeling PD.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Modelos Animales de Enfermedad
/
Neurotoxinas
Límite:
Animals
Idioma:
En
Revista:
ASN Neuro
Asunto de la revista:
NEUROLOGIA
/
QUIMICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China