Resveratrol inhibits angiotensin IIinduced proliferation of A7r5 cells and decreases neointimal hyperplasia by inhibiting the CaMKIIHDAC4 signaling pathway.
Mol Med Rep
; 18(1): 1007-1014, 2018 Jul.
Article
en En
| MEDLINE
| ID: mdl-29845301
ABSTRACT
Resveratrol has been reported to inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia following arterial injury; however, the underlying mechanisms remain unclear. The present study was designed to investigate the effects of resveratrol on angiotensin II (AngII)induced proliferation of A7r5 cells and explore the molecular mechanisms responsible for the observed effects. Resveratrol inhibited cell proliferation and migration, and decreased the AngIIinduced protein expression of αsmooth muscle actin (αSMA), proliferating cell nuclear antigen (PCNA) and cyclindependent kinase 4 (CDK4). Resveratrol inhibited AngIIinduced activation of intracellular Ca2+/calmodulindependent protein kinase II (CaMKII) and histone deacetylases 4 (HDAC4), as well as blocking AngIIinduced cell cycle progression from the G0/G1 to Sphase. In vivo, 4weeks of resveratrol treatment decreased the neointima area and the neointima/media area ratio in rats following carotid balloon injury. Resveratrol also inhibited the protein expression of total and phosphorylated CaMKII and HDAC4 in the injured arteries. In conclusion, the present study demonstrated that resveratrol attenuated AngIIinduced cell proliferation and neointimal hyperplasia by inhibiting the CaMKIIHDAC4 signaling pathway. These findings suggest that resveratrol may potentially prevent arterial restenosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estilbenos
/
Angiotensina II
/
Transducción de Señal
/
Ciclo Celular
/
Proteína Quinasa Tipo 2 Dependiente de Calcio Calmodulina
/
Neointima
/
Histona Desacetilasas
Límite:
Animals
Idioma:
En
Revista:
Mol Med Rep
Año:
2018
Tipo del documento:
Article