Immunohistochemical expression of myofibroblasts, TGF-ß1 and IFN-γ in oral fibrous lesions.
Arch Oral Biol
; 93: 80-86, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-29857279
ABSTRACT
OBJECTIVE:
Analyze the presence of myofibroblasts (MFBs) in oral fibrous lesions and investigate TGF-ß1 and IFN-γ expression by immunohistochemistry during their differentiation.DESIGN:
Twenty giant cell fibromas (GCFs), 20 fibromas (FIBs), and 20 fibrous hyperplasias (FHs) were selected. To evaluate the presence of MFBs, anti-α-SMA-immunoreactive cells were quantified in connective tissue. TGF-ß1 and IFN-γ expressions were evaluated in epithelial and connective tissue by determining the percentage of immunoreactive cells.RESULTS:
Higher MFBs concentrations were observed in GCFs (median of 20.00), followed by FHs (15.00) and FIBs (14.00) (Pâ¯=â¯0.072). No significant correlation between TGF-ß1 or IFN-γ immunoexpression and the number of MFBs in oral fibrous lesions was observed (Pâ¯>â¯0.05).CONCLUSIONS:
The higher density of MFBs found in GCFs, followed by FHs and FIBs, reaffirms the fibrogenic role of these cells, while the higher concentrations detected in GCFs, including evidence of giant MFBs, also suggest a role in the neoplastic behavior of these lesions. No correlation was observed between TGF-ß1 and IFN-γ in the myofibroblastic transdifferentiation process of the analyzed lesions.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Boca
/
Inmunohistoquímica
/
Interferón gamma
/
Factor de Crecimiento Transformador beta1
/
Miofibroblastos
/
Fibroma
Límite:
Humans
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Arch Oral Biol
Año:
2018
Tipo del documento:
Article